DR. PETER JENSEN: Well investigators, the researchers, began to apply the approaches and the methods used to study depression in adults to children. And lo and behold, they found it wasn't just a stage. And if you had all the signs and symptoms that adults have, as a young child, you're probably at much greater risk even than when an adult has onset with depression. It has a much more difficult problematic course. And early intervention is quite critical.
LISA CLARK: Are there certain types of children who are more prone to depression?
DR. PETER JENSEN: We think that family history is important, so genetic factors probably play a role. But there are other factors that are also suspect. Prolonged medical illnesses might serve as a precipitant. Stress factors occurring throughout a substantial period of one's life. Some people have demonstrated that the loss of significant loved ones in early critical periods, in the first five years of life, might lead to later problems, and later a modest increased risk for depression. Some of the other things we don't think about, but also are linked to depression, are substance use. And so prolonged substance use probably is linked to depression as well.
LISA CLARK: For the child to have had substance use, or the mother during gestation?
DR. PETER JENSEN: Both.
LISA CLARK: Now girls are more prone to depression at certain stages in development. When is that?